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One of the leading brand medications that have been introduced within this class is known as Levaquin. Contact your health care provider if you have any questions. Medications will cause health effects and serious reactions when taken with Levaquin. Levofloxacin is effective against a number of gram-positive and gram-negative bacteria. Levaquin can increase the effects of the anticoagulant warfarin. Follow the procedures you are taught when you use a dose. Follow the procedures you are taught when you use a dose.