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If Lexapro side effects occur. Escitalopram helps to restore the brain's chemical balance by increasing the available supply of serotonin, a natural substance in the brain, is an important factor in the development and severity of depressive symptoms, such as sad mood, fatigue, lack of pleasure, etc. Escitalopram appears to relieve depression by increasing serotonin levels with minimal effect on many of the other chemicals in the brain that helps maintain mental balance.