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If you take Synthroid with an appetite-suppressant medication. If your thyroid production is low. Levothyroxine sodium. If you are taking Synthroid to make up for a lack of natural hormone, it is not effective as a weight-loss drug and should not be used as such. Synthroid should be used with caution, when taking Synthroid. Synthroid has profound effects on the body. Synthroid may cause seizures at the beginning of treatment, although this is rare.