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By the first nerve cell. To begin with. Lexapro is an antidepressant in a group of drugs called selective serotonin reuptake inhibitor used to treat depression and generalized anxiety disorder. Lexapro is used to treat depression. There is a serious condition that, if left untreated, can cause major problems in your life. Lexapro blocks the re-absorption of serotonin by the first nerve cell.